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Article

Getting from an RNA world to modern cells just got a little easier.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 2006

Poole Anthony M

Abstract excerpt

Our understanding of the early steps in the evolution of life is hampered by a Catch-22: Darwinian selection leading to longer genomes requires as prerequisite increased replicative fidelity. Yet a genome at capacity cannot increase in size; it will be catastrophically mutated out of existence if fidelity has not already increased. Traditionally the problem has been considered for genotypes but can be down-sized...

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PMID: 16435297
DOI: 10.1002/bies.20367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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