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Article

M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop.

Journal of experimental & clinical cancer research : CR - 6 Jan 2022

You Yuanhe, Tian Zhuowei, Du Zhong, Wu Kailiu, Xu Guisong, Dai Meilu, Wang Yan'an, Xiao Meng

Abstract excerpt

BACKGROUND: Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma (OSCC). However, the functional roles and associated molecular mechanisms of the activated M1-like TAMs need to be further clarified in OSCC. METHODS: Conditioned...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34991668
DOI: 10.1186/s13046-021-02222-z
PMCID: PMC8734049

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