Article
A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus.
Frontiers in cellular and infection microbiology - 1 Jan 2021
Ashoor Dana, Ben Khalaf Noureddine, Marzouq Maryam, Jarjanazi Hamdi, Chlif Sadok, Fathallah M Dahmani
Abstract excerpt
SARS-CoV-2 infectivity is largely determined by the virus Spike protein binding to the ACE2 receptor. Meanwhile, marked infection rate differences were reported between populations and individuals. To understand the disease dynamic, we developed a computational approach to study the implications of both SARS-CoV-2 RBD mutations and ACE2 polymorphism on the stability of the virus-receptor complex. We used the 6LZG...
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