Article

Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy

2024-07-22

Abstract excerpt

Linking disease phenotypes with molecular targets is key to the rational design of treatment interventions. Resistance to the chemotherapeutic cisplatin is one of the major factors limiting the clinical utility of this therapy, which is central to the treatment of a variety of solid malignancies. In this study, we couple the upregulation of a chemoresistant factor, the glutamate-cystine antiporter SLC7A11, with th...

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Literature Corpus work: 509ffdc3-cba5-50d0-a1ab-b2f00cef58fc
DOI: 10.1101/2024.07.19.604261

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Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapyDOI 10.1101/2024.07.19.604261Read

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