Article
Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly.
Molecular cancer - 26 Nov 2019
Shi Qing, Zhu Yasheng, Ma Jian, Chang Kun, Ding Dongling, Bai Yang, Gao Kun, Zhang Pingzhao, Mo Ren, Feng Kai, Zhao Xiaying, Zhang Liang, Sun Huiru, Jiao Dongyue, Chen Yingji, Sun Yinghao, Zhao Shi-Min, Huang Haojie, Li Yao, Ren Shancheng, Wang Chenji
Abstract excerpt
BACKGROUND: The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in primary prostate cancer, but how SPOP mutations contribute to prostate cancer pathogenesis remains poorly understood. Stress granules (SG) assembly is an evolutionarily conserved strategy for survival of cells under stress, and often upregulated in human cancers. We investigated the role of SPOP mutations...
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