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Article

The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance.

Journal of clinical psychopharmacology - 1 Apr 2014

Wang Sheng-Chang, Tsou Hsiao-Hui, Chung Ren-Hua, Chang Yao-Sheng, Fang Chiu-Ping, Chen Chia-Hui, Ho Ing-Kang, Kuo Hsiang-Wei, Liu Shu Chih, Shih Yu-Huei, Wu Hsiao-Yu, Huang Bo-Hau, Lin Keh-Ming, Chen Andrew C H, Hsiao Chin-Fu, Liu Yu-Li

Abstract excerpt

Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity. This study tested the hypotheses that the genetic polymorphisms in the κ-opioid receptor 1 (OPRK1) gene region are associated with methadone treatment responses in a Taiwan methadone maintenance treatment (MMT) cohort. Seventeen single nucleotide polymorphisms (SNPs) in OPRK1 were selected and genotyped on DNA of 366 MMT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24525640
DOI: 10.1097/JCP.0000000000000082

Genes

OPRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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