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Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL

4 Jan 2022

Abstract excerpt

BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop region and mitochondrial DNA copy number (mtDNAcn) play a critical role in the maintenance of mitochondrial function. However, the association between D-loop region methylation, mtDNAcn and...

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PMID: 34983647
DOI: 10.1186/s13148-021-01225-z

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