Article
Mitochondrial dysfunction associated with a mutation in the Notch3 gene in a CADASIL family.
Neurology - 9 Oct 2001
de la Peña P, Bornstein B, del Hoyo P, Fernández-Moreno M A, Martín M A, Campos Y, Gómez-Escalonilla C, Molina J A, Cabello A, Arenas J, Garesse R
Abstract excerpt
BACKGROUND: Cerebral autosomal arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by recurrent subcortical ischemic strokes and dementia caused by mutations in the Notch3 gene. In Drosophila melanogaster, Notch signaling has a pleiotropic effect, affecting most tissues of the organism during development. OBJECTIVE: To characterize a potential mitochondrial dysfunction...
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