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Article

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes

1 Feb 1999

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Share to Genetic and Kidney Cyst Diseases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 9988265
DOI: 10.1038/5944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotesPMID 9988265Read ↗

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation.Semantic proximity Read ↗

A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.Semantic proximity Read ↗

Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.Semantic proximity Read ↗

The Pathophysiology of Inherited Renal Cystic DiseasesSemantic proximity Read ↗

A novel ARPKD mouse model with near-complete deletion of the Polycystic Kidney and Hepatic Disease 1 (Pkhd1) genomic locus presents with multiple phenotypes but not renal cysts.Semantic proximity Read ↗

Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects.Semantic proximity Read ↗

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.Semantic proximity Read ↗

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.Semantic proximity Read ↗

Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.Semantic proximity Read ↗

Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult miceSemantic proximity Read ↗

PKD1 mono-allelic knockout is sufficient to trigger renal cystogenesis in a mini-pig model.Semantic proximity Read ↗

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.Semantic proximity Read ↗

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