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Article

GATA3 functions downstream of BRCA1 to suppress EMT in breast cancer

1 Jan 2021

Abstract excerpt

Purpose: Functional loss of BRCA1 is associated with poorly differentiated and metastatic breast cancers that are enriched with cancer stem cells (CSCs). CSCs can be generated from carcinoma cells through an epithelial-mesenchymal transition (EMT) program. We and others have previously demonstrated that BRCA1 suppresses EMT and regulates the expression of multiple EMT-related transcription factors. However, the...

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PMID: 34373738
DOI: 10.7150/thno.59280

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