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Article

High prevalence of TERT aberrations in myxoid liposarcoma: TERT reactivation may play a crucial role in tumorigenesis.

Cancer science - 1 Mar 2022

Kunieda Junko, Yamashita Kyoko, Togashi Yuki, Baba Satoko, Sakata Seiji, Inamura Kentaro, Ae Keisuke, Matsumoto Seiichi, Machinami Rikuo, Kitagawa Masanobu, Takeuchi Kengo

Abstract excerpt

Myxoid liposarcoma (MLPS) is genetically characterized by FUS-DDIT3 or EWSR1-DDIT3 gene fusion and the high frequency of hotspot mutations (C228T or C250T) in the promoter region of telomerase reverse transcriptase (TERT) that encodes the TERT protein. The latter leads to telomerase reactivation, a mechanism of telomere maintenance. Although the TERT promoter hotspot mutation is a poor prognostic factor in...

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Identifiers

PMID: 34971481
DOI: 10.1111/cas.15256
PMCID: PMC8898734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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