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Genotyping of circulating cell‐free DNA enables noninvasive tumor detection in myxoid liposarcomas

19 Feb 2019

Abstract excerpt

Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years after diagnosis. In this study we investigated circulating free DNA (cfDNA) and tumor-specific genetic alterations therein (circulating tumor DNA, ctDNA) as diagnostic biomarkers. Plasma concentrations and fragmentation of cfDNA was analyzed with...

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PMID: 30779112
DOI: 10.1002/ijc.32216

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