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Article

Computational refinement identifies functional destructive single nucleotide polymorphisms associated with human retinoid X receptor gene.

Journal of biomolecular structure & dynamics - 1 Mar 2023

Sarkar Soumalya, Gupta Vivek K, Sharma Samridhi, Shen Ting, Gupta Veer, Mirzaei Mehdi, Graham Stuart L, Chitranshi Nitin

Abstract excerpt

Alterations in the nuclear retinoid X receptor (RXRs) signalling have been implicated in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis and glaucoma. Single nucleotide polymorphisms (SNPs) are the main cause underlying single nucleic acid variations which in turn determine heterogeneity within various populations. These genetic polymorphisms have been...

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PMID: 34971346
DOI: 10.1080/07391102.2021.2021991

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