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Article

Implementation of computational approaches to explore the deleterious effects of non-synonymous SNPs on pRB protein.

Journal of biomolecular structure & dynamics - 1 Oct 2022

Rahaman Md Mashiur, Islam Rahatul, Jewel G M Nurnabi Azad, Hoque Hammadul

Abstract excerpt

Retinoblastoma 1 (RB1) is the first discovered tumor suppressor gene and recognized as the simple model system whose encoded defective protein can cause a pediatric cancer retinoblastoma. It functions as a negative regulator of the cell cycle through the interactions with members of the E2F transcription factors family. The protein of the RB1 gene (pRB) is engaged in various cell cycle processes including...

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Identifiers

PMID: 33682629
DOI: 10.1080/07391102.2021.1896385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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