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Article

Characterization of missense nonsynonymous single-nucleotide polymorphism of runt-related transcription factor-2 gene - An in silico approach.

Indian journal of pharmacology - 1 May 2024

Shiv Ragul, Rakeswari, Farjana Nilofer, Subbiah Usha, Ajith Athira, Balaji Anitha, Mohanasatheesh S

Abstract excerpt

OBJECTIVES: Single-nucleotide polymorphism (SNP) codes for multiple amino acids, impacting protein functions and disease prognosis. Runt-related transcription factor-2 (RUNX2), a transcription factor linked to osteoblast differentiation, regulates cell proliferation in endothelium and osteoblastic cells. Understanding Runx2's role in nonosseous tissues is rapidly advancing. This study aims to identify harmful...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39078184
DOI: 10.4103/ijp.ijp_533_23
PMCID: PMC11286098

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