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Article

Role of genetic mutations in folate-related enzyme genes on Male Infertility.

Scientific reports - 9 Nov 2015

Liu Kang, Zhao Ruizhe, Shen Min, Ye Jiaxin, Li Xiao, Huang Yuan, Hua Lixin, Wang Zengjun, Li Jie

Abstract excerpt

Several studies showed that the genetic mutations in the folate-related enzyme genes might be associated with male infertility; however, the results were still inconsistent. We performed a meta-analysis with trial sequential analysis to investigate the associations between the MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G mutations and the MTHFR haplotype with the risk of male infertility. Overall, a total of...

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Share to Asthenozoospermia
Share to Folic Acid
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oligospermia

Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 26549413
DOI: 10.1038/srep15548
PMCID: PMC4637885

Genes

MTHFR
MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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