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Article

The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning.

Psychoneuroendocrinology - 1 May 2018

Felmingham Kim L, Zuj Daniel V, Hsu Ken Chia Ming, Nicholson Emma, Palmer Matthew A, Stuart Kimberley, Vickers James C, Malhi Gin S, Bryant Richard A

Abstract excerpt

The low expression Met allele of the BDNF Val66Met polymorphism is associated with impaired fear extinction in healthy controls, and poorer response to exposure therapy in patients with Posttraumatic Stress Disorder (PTSD). Given that fear extinction underlies exposure therapy, this raises the question of the impact of BDNFVal66Met polymorphism on fear extinction in PTSD, yet this question has not yet been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29550677
DOI: 10.1016/j.psyneuen.2018.03.002

Genes

BDNF

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