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Article

The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice.

The European journal of neuroscience - 1 Mar 2005

Kalesnykas Giedrius, Roschier Ulla, Puoliväli Jukka, Wang Jun, Miettinen Riitta

Abstract excerpt

The degeneration of the basal forebrain cholinergic system plays an important role in cognitive deterioration in aging and Alzheimer's disease. Brain cholinergic neurons and their projections are affected by changes in the circulating levels of estrogens, which exert their effects mainly through the estrogen receptors. In this study, we investigated the effect of aging, estrogen status and transgenic genotype on...

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Source

Identifiers

PMID: 15813954
DOI: 10.1111/j.1460-9568.2005.03953.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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