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Article

Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome.

G3 (Bethesda, Md.) - 7 May 2024

Sember Eileen, Chennakesavula Ranga, Beard Breanna, Opoola Mubaraq, Hwangbo Dae-Sung

Abstract excerpt

Werner syndrome (WS) is a rare genetic disease in humans, caused by mutations in the WRN gene that encodes a protein containing helicase and exonuclease domains. WS is characterized by symptoms of accelerated aging in multiple tissues and organs, involving increased risk of cancer, heart failure, and metabolic dysfunction. These conditions ultimately lead to the premature mortality of patients with WS. In this...

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Identifiers

PMID: 38491858
DOI: 10.1093/g3journal/jkae056
PMCID: PMC11075538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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