Article
Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease.
Cells - 20 Dec 2021
Morsy Yasser, Brillant Nathalie, Franc Yannick, Scharl Michael, Wawrzyniak Marcin, On Behalf Of The Swiss Ibd Cohort Study Group
Abstract excerpt
Background: The single nucleotide polymorphism (SNP) rs1042058 within the gene locus encoding tumor progression locus 2 (TPL2) has been recently identified as a risk gene for inflammatory bowel disease (IBD). TPL2 has been shown to regulate pro-inflammatory signaling and cytokine secretion, while inhibition of TPL2 decreases intestinal inflammation in vivo. However, the clinical and molecular implications of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.