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Article

The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.

PloS one - 1 Jan 2018

Yilmaz Bahtiyar, Spalinger Marianne R, Biedermann Luc, Franc Yannick, Fournier Nicolas, Rossel Jean-Benoit, Juillerat Pascal, Rogler Gerhard, Macpherson Andrew J, Scharl Michael

Abstract excerpt

BACKGROUND: Genetic risk factors, intestinal microbiota and a dysregulated immune system contribute to the pathogenesis of inflammatory bowel disease (IBD). We have previously demonstrated that dysfunction of protein tyrosine phosphatase non-receptor type 2 (PTPN2) and PTPN22 contributes to alterations of intestinal microbiota and the onset of chronic intestinal inflammation in vivo. Here, we investigated the...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29965986
DOI: 10.1371/journal.pone.0199664
PMCID: PMC6028086

Genes

PTPN2
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.PMID 29965986Read ↗

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.Semantic proximity Read ↗

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.Semantic proximity Read ↗

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.Semantic proximity Read ↗

Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.Semantic proximity Read ↗

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Differential association of two PTPN22 coding variants with Crohn’s disease and ulcerative colitisSemantic proximity Read ↗

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A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.Semantic proximity Read ↗

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