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Article

Functional Toll-Like Receptor (TLR)2 polymorphisms in the susceptibility to inflammatory bowel disease.

PloS one - 1 Jan 2017

Török Helga Paula, Bellon Victor, Konrad Astrid, Lacher Martin, Tonenchi Laurian, Siebeck Matthias, Brand Stephan, De Toni Enrico Narciso

Abstract excerpt

BACKGROUND: The recent genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) suggest significant genetic overlap with complex mycobacterial diseases like tuberculosis or leprosy. TLR variants have previously been linked to susceptibility for mycobacterial diseases. Here we investigated the contribution to IBD risk of two TLR2 polymorphisms, the low-prevalence variant Arg753Gln and the GTn...

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Source

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Identifiers

PMID: 28388655
DOI: 10.1371/journal.pone.0175180
PMCID: PMC5384663

Genes

TLR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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