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Article

Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants.

Inflammatory bowel diseases - 1 May 2013

Marcil Valerie, Mack David R, Kumar Vijay, Faure Christophe, Carlson Christopher S, Beaulieu Patrick, Israel David, Krupoves Alfreda, Costea Irina, Lambrette Philippe, Grimard Guy, Dong Jinsong, Seidman Ernest G, Amre Devendra K, Levy Emile

Abstract excerpt

BACKGROUND: Although genome-wide association studies (GWAS) and subsequent meta-analyses have confirmed associations between the PTPN2 (protein tyrosine phosphatase, nonreceptor type 2) gene and Crohn's disease (CD), the potential causal variants remain unidentified. We aimed to dissect potential causal CD-associated PTPN2 variants, assess their functional significance, and relate PTPN2 protein expression with...

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Source

Identifiers

PMID: 23518806
DOI: 10.1097/MIB.0b013e318280b181

Genes

PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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