Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients.

doi:10.3390/cells9112409

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients.

Cells - 3 Nov 2020

Ohashi Riuko, Umezu Hajime, Sato Ayako, Abé Tatsuya, Kondo Shuhei, Daigo Kenji, Sato Seijiro, Hara Norikazu, Miyashita Akinori, Ikeuchi Takeshi, Motoyama Teiichi, Kishi Masashi, Nagaoka Tadahiro, Horiuchi Keiko, Shiga Atsushi, Okuda Shujiro, Sekiya Tomoki, Ohtsubo Aya, Ichikawa Kosuke, Kagamu Hiroshi, Kikuchi Toshiaki, Watanabe Satoshi, Tanuma Jun-Ichi, Schraml Peter, Hamakubo Takao, Tsuchida Masanori, Ajioka Yoichi

Abstract excerpt

Ribosomal RNA (rRNA), the most abundant non-coding RNA species, is a major component of the ribosome. Impaired ribosome biogenesis causes the dysfunction of protein synthesis and diseases called "ribosomopathies," including genetic disorders with cancer risk. However, the potential role of rRNA gene (rDNA) alterations in cancer is unknown. We investigated germline and somatic single-nucleotide variants (SNVs) in...

Topics

Adenocarcinoma of Lung
Aged
Asian People
Base Sequence
Cell Line, Tumor
Dactinomycin
Databases, Genetic
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Loci

Germ-Line Mutation

Humans

Lung Neoplasms

Male

Middle Aged

Multivariate Analysis

Neoplasm Recurrence, Local

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 33153169
DOI: 10.3390/cells9112409
PMCID: PMC7692307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent Germline and Somatic Single Nucleotide Variants in the Promoter Region of the Ribosomal RNA Gene in Japanese Lung Adenocarcinoma Patients.PMID 33153169Read ↗

Human rDNA and Cancer.Semantic proximity Read ↗

An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells.Semantic proximity Read ↗

Downregulation of ribosomal RNA (rRNA) genes in human head and neck squamous cell carcinoma (HNSCC) cells is linked to rDNA promoter hypermethylationSemantic proximity Read ↗

Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation.Semantic proximity Read ↗

Diversity of ribosomes at the level of rRNA variation associated with human health and disease.Semantic proximity Read ↗

Diversity of ribosomes at the level of rRNA variation associated with human health and diseaseSemantic proximity Read ↗

Alterations in the ribosomal machinery in cancer and hematologic disordersSemantic proximity Read ↗

Widespread germline genetic heterogeneity of human ribosomal RNA genesSemantic proximity Read ↗

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.Semantic proximity Read ↗

Role of ribosomal protein mutations in tumor development (Review).Semantic proximity Read ↗

Potential of Mitochondrial Ribosomal Genes as Cancer Biomarkers Demonstrated by Bioinformatics ResultsSemantic proximity Read ↗

How Ribosomes Translate Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.