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Whole exome analysis reveals the genomic profiling related to chemo-resistance in Chinese population with limited-disease small cell lung cancer.

Cancer medicine - 1 Jan 2023

Yu Jiangyong, Zhao Shuangtao, Su Zhe, Song Chengli, Wu Lihong, Wang Jingbo, Bi Nan, Wang Lvhua

Abstract excerpt

PURPOSE: The mechanism of chemo-resistance in small cell lung cancer (SCLC) is unclear. This study aims to explore the resistance-related genomic profiles of residual tumors after neo-adjuvant chemotherapy (NAC) in SCLC through the whole-exome sequencing (WES). EXPERIMENTAL DESIGN: A total of 416 limited diseases (LD) SCLC patients underwent surgery were retrospectively analyzed, of which 40 patients received...

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Identifiers

PMID: 35735600
DOI: 10.1002/cam4.4950
PMCID: PMC9883427

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