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Article

A biomarker exploration in small-cell lung cancer for brain metastases risk and prophylactic cranial irradiation therapy efficacy.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2024

Li Li, Liu Ning, Zhou Tao, Qin Xueting, Song Xiaoyu, Wang Song, Pang Jiaohui, Ou Qiuxiang, Wang Yong, Zhang Dexian, Li Jiaran, Xu Fuhao, Shi Shuming, Yu Jinming, Yuan Shuanghu

Abstract excerpt

BACKGROUND: Small-cell lung cancer (SCLC) is an aggressive malignancy with a poor prognosis. Limited-stage (LS)-SCLC comprises only one-third of SCLC cases, resulting in limited molecularly targeted therapies and treatment options. Despite advances in thoracic and cranial irradiation leading to improved outcomes, a notable proportion of patients develop brain metastasis (BM), highlighting the importance of...

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Identifiers

PMID: 39340898
DOI: 10.1016/j.lungcan.2024.107959

Genes

RB1
FLT4
BCL3

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