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Article

The genomic alterations in glioblastoma influence the levels of CSF metabolites.

Acta neuropathologica communications - 19 Jan 2024

Wang Daniel H, Fujita Yoko, Dono Antonio, Rodriguez Armendariz Ana G, Shah Mauli, Putluri Nagireddy, Pichardo-Rojas Pavel S, Patel Chirag B, Zhu Jay-Jiguang, Huse Jason T, Parker Kerrigan Brittany C, Lang Frederick F, Esquenazi Yoshua, Ballester Leomar Y

Abstract excerpt

Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility of CSF biomarkers. While some studies show the utility of CSF cell-free DNA analysis, studies analyzing CSF metabolites in patients with glioblastoma are limited. Diffuse gliomas have altered cellular metabolism. For example, mutations in isocitrate...

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Identifiers

PMID: 38243318
DOI: 10.1186/s40478-024-01722-1
PMCID: PMC10799404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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