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Article

Identification of Metabolomic Markers in Frozen or Formalin-Fixed and Paraffin-Embedded Samples of Diffuse Glioma from Adults.

International journal of molecular sciences - 24 Nov 2023

Chardin David, Jing Lun, Chazal-Ngo-Mai Mélanie, Guigonis Jean-Marie, Rigau Valérie, Goze Catherine, Duffau Hugues, Virolle Thierry, Pourcher Thierry, Burel-Vandenbos Fanny

Abstract excerpt

The aim of this study was to identify metabolomic signatures associated with the gliomagenesis pathway (IDH-mutant or IDH-wt) and tumor grade of diffuse gliomas (DGs) according to the 2021 WHO classification on frozen samples and to evaluate the diagnostic performances of these signatures in tumor samples that are formalin-fixed and paraffin-embedded (FFPE). An untargeted metabolomic study was performed using...

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PMID: 38069019
DOI: 10.3390/ijms242316697
PMCID: PMC10705927

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