Article
Linking epigenetic signature and metabolic phenotype in IDH mutant and IDH wildtype diffuse glioma.
Neuropathology and applied neurobiology - 1 Apr 2021
Braun Yannick, Filipski Katharina, Bernatz Simon, Baumgarten Peter, Roller Bastian, Zinke Jenny, Zeiner Pia S, Ilina Elena, Senft Christian, Ronellenfitsch Michael W, Plate Karl H, Bähr Oliver, Hattingen Elke, Steinbach Joachim P, Mittelbronn Michel, Harter Patrick N
Abstract excerpt
AIMS: Changes in metabolism are known to contribute to tumour phenotypes. If and how metabolic alterations in brain tumours contribute to patient outcome is still poorly understood. Epigenetics impact metabolism and mitochondrial function. The aim of this study is a characterisation of metabolic features in molecular subgroups of isocitrate dehydrogenase mutant (IDHmut) and isocitrate dehydrogenase wildtype...
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