Article
Metabolomic Profiles of Human Glioma Inform Patient Survival.
Antioxidants & redox signaling - 1 Nov 2023
Scott Andrew J, Correa Luis O, Edwards Donna M, Sun Yilun, Ravikumar Visweswaran, Andren Anthony C, Zhang Li, Srinivasan Sudharsan, Jairath Neil, Verbal Kait, Muraszko Karin, Sagher Oren, Carty Shannon A, Hervey-Jumper Shawn, Orringer Daniel, Kim Michelle M, Junck Larry, Umemura Yoshie, Leung Denise, Venneti Sriram, Camelo-Piragua Sandra, Lawrence Theodore S, Ippolito Joseph E, Al-Holou Wajd N, Chinnaiyan Prakash, Heth Jason, Rao Arvind, Lyssiotis Costas A, Wahl Daniel R
Abstract excerpt
Aims: Targeting tumor metabolism may improve the outcomes for patients with glioblastoma (GBM). To further preclinical efforts targeting metabolism in GBM, we tested the hypothesis that brain tumors can be stratified into distinct metabolic groups with different patient outcomes. Therefore, to determine if tumor metabolites relate to patient survival, we profiled the metabolomes of human gliomas and correlated...
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