Article
Rats exhibit age-related mosaic loss of chromosome Y.
Communications biology - 21 Dec 2021
Orta Alberto H, Bush Stephen J, Gutiérrez-Mariscal Mariana, Castro-Obregón Susana, Jaimes-Hoy Lorraine, Grande Ricardo, Vázquez Gloria, Gorostieta-Salas Elisa, Martínez-Pacheco Mónica, Díaz-Barba Karina, Cornejo-Páramo Paola, Sanchez-Flores Alejandro, Székely Tamas, Urrutia Araxi O, Cortez Diego
Abstract excerpt
Mosaic loss of the Y chromosome (LOY) is the most frequent chromosomal aberration in aging men and is strongly correlated with mortality and disease. To date, studies of LOY have only been performed in humans, and so it is unclear whether LOY is a natural consequence of our relatively long lifespan or due to exposure to human-specific external stressors. Here, we explored whether LOY could be detected in rats. We...
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