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Article

Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant.

Journal of pharmacological sciences - 1 Jan 2022

Hirakawa Haruki, Taguchi Kei, Murakawa Seiya, Asano Masaya, Noguchi Soma, Kikkawa Satoshi, Harada Kana, Adachi Naoko, Ueyama Takehiko, Hide Izumi, Tanaka Shigeru, Sakai Norio

Abstract excerpt

Flurbiprofen, a nonsteroidal anti-inflammatory drug, reportedly exhibits chemical chaperone activity. Herein, we investigated the role of flurbiprofen in regulating serotonin transporter (SERT) function via membrane trafficking. We used COS-7 cells transiently expressing wild-type (WT) SERT or a C-terminus-deleted mutant of SERT (SERTΔCT), a misfolded protein. Flurbiprofen treatment reduced the expression of...

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Identifiers

PMID: 34924125
DOI: 10.1016/j.jphs.2021.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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