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Article

Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

The Journal of biological chemistry - 10 Dec 2010

El-Kasaby Ali, Just Herwig, Malle Elisabeth, Stolt-Bergner Peggy C, Sitte Harald H, Freissmuth Michael, Kudlacek Oliver

Abstract excerpt

The serotonin transporter (SERT) is a member of the SLC6 family of solute carriers. SERT plays a crucial role in synaptic neurotransmission by retrieving released serotonin. The intracellular carboxyl terminus of various neurotransmitter transporters has been shown to be important for the correct delivery of SLC6 family members to the cell surface. Here we studied the importance of the C terminus in trafficking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20889976
DOI: 10.1074/jbc.M110.118000
PMCID: PMC2998113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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