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Article

Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15.

BMC immunology - 18 Dec 2021

Rodríguez-Álvarez Yunier, Batista-Roche Lino Gerardo, Llopiz-Arzuaga Alexey, Puente-Pérez Pedro, Martínez-Castillo Rafael, Castro-Velazco Jorge, Santos-Savio Alicia

Abstract excerpt

BACKGROUND: Interleukin (IL)-15 is a proinflammatory T-cell growth factor overexpressed in several autoimmune diseases such as rheumatoid arthritis. Our initial strategy to neutralize the increased levels of IL-15 consisted in a vaccine candidate based on the recombinant modified human IL-15 (mhIL-15) mixed with the alum adjuvant. A previous study in non-human primates Macaca fascicularis has shown that...

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Identifiers

PMID: 34922462
DOI: 10.1186/s12865-021-00470-4
PMCID: PMC8684083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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