Article
Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Apr 2012
Millington Timothy, Koulmanda Maria, Ng Choo, Boskovic Svjetlan, Nadazdin Ognjenka M, Benichou Gilles, Zheng Xin Xiao, Strom Terry B, Madsen Joren C
Abstract excerpt
BACKGROUND: To tilt the immunologic balance toward tolerance and away from rejection, non-human primate recipients of cardiac allografts were treated with interleukin (IL)-2/Fc, mutant (m) antagonist type mIL-15/Fc, and sirolimus. METHODS: Heterotopic heart transplants were performed on 8 fully m...
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