Article
Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution.
Nature genetics - 1 Apr 2021
Gokhman David, Agoglia Rachel M, Kinnebrew Maia, Gordon Wei, Sun Danqiong, Bajpai Vivek K, Naqvi Sahin, Chen Coral, Chan Anthony, Chen Chider, Petrov Dmitri A, Ahituv Nadav, Zhang Honghao, Mishina Yuji, Wysocka Joanna, Rohatgi Rajat, Fraser Hunter B
Abstract excerpt
Gene regulatory divergence is thought to play a central role in determining human-specific traits. However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induced pluripotent stem cells to study gene expression separating these species. The tetraploid hybrid cells allowed us to separate cis- from trans-regulatory effects, and to control for...
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