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Article

Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.

The Journal of biological chemistry - 29 May 2015

Rajbhandari Prashant, Ozers Mary Szatkowski, Solodin Natalia M, Warren Christopher L, Alarid Elaine T

Abstract excerpt

The transcriptional activity of estrogen receptor α (ERα), the key driver of breast cancer proliferation, is enhanced by multiple cellular interactions, including phosphorylation-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 (activation function 1) domain of ERα. Because both ERα and Pin1 have...

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Identifiers

PMID: 25866209
DOI: 10.1074/jbc.M114.621698
PMCID: PMC4447953

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α.PMID 25866209Read ↗

Regulation of Estrogen Receptor α N-Terminus Conformation and Function by Peptidyl Prolyl Isomerase Pin1Semantic proximity Read ↗

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.Semantic proximity Read ↗

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read ↗

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The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.Semantic proximity Read ↗

Targeting carcinogenesis: A role for the prolyl isomerase Pin1?Semantic proximity Read ↗

Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain.Semantic proximity Read ↗

Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancerSemantic proximity Read ↗

Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradationSemantic proximity Read ↗

Molecular Cloning and Characterization of PELP1, a Novel Human Coregulator of Estrogen Receptor αSemantic proximity Read ↗

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