Article
Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows.
Small (Weinheim an der Bergstrasse, Germany) - 1 Jun 2021
Voith von Voithenberg Lena, Kashyap Aditya, Opitz Lennart, Aquino Catharine, Sykes Timothy, Nieser Maike, Petrini Lorenzo F T, Enrriquez Casimiro Nadia, van Kooten Xander F, Biskup Saskia, Schlapbach Ralph, Schraml Peter, Kaigala Govind V
Abstract excerpt
In cancer research, genomic profiles are often extracted from homogenized macrodissections of tissues, with the histological context lost and a large fraction of material underutilized. Pertinently, the spatial genomic landscape provides critical complementary information in deciphering disease heterogeneity and progression. Microscale sampling methods such as microdissection to obtain such information are often...
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