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Article

Essential roles of buried phenylalanine in the structural stability of thioredoxin from a psychrophilic Arctic bacterium Sphingomonas sp.

PloS one - 1 Jan 2021

Nguyen Thu-Thuy, Hoang Trang, Tran Kiet N, Kim Hyeonji, Jang Sei-Heon, Lee ChangWoo

Abstract excerpt

Thioredoxin (Trx), a small redox protein, exhibits thermal stability at high temperatures regardless of its origin, including psychrophiles. Trxs have a common structure consisting of the central β-sheet flanked by an aliphatic cluster on one side and an aromatic cluster on the other side. Although the roles of aromatic amino acids in the folding and stability of proteins have been studied extensively, the...

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Identifiers

PMID: 34910731
DOI: 10.1371/journal.pone.0261123
PMCID: PMC8673628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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