EvoMut: A computational framework for engineering oxidative stability in proteins.

Abstract excerpt

Amino acid oxidation is a major cause of protein instability and loss of function in therapeutic and industrial settings. Although methionine, cysteine, tryptophan, tyrosine, histidine, lysine, and arginine residues are widely recognized as oxidation-prone, only a subset of such residues is dominant functional hotspots, and not all are suitable targets for mutation. Identifying these vulnerable, yet engineerable,...

Topics

• Oxidation-Reduction
• Protein Engineering
• Proteins
• Protein Stability
• Computational Biology
• Models, Molecular