Article
Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple-sequence alignments.
Biochemistry - 17 Jul 2012
Dietrich Susanne, Borst Nadine, Schlee Sandra, Schneider Daniel, Janda Jan-Oliver, Sterner Reinhard, Merkl Rainer
Abstract excerpt
The analysis of a multiple-sequence alignment (MSA) with correlation methods identifies pairs of residue positions whose occupation with amino acids changes in a concerted manner. It is plausible to assume that positions that are part of many such correlation pairs are important for protein function or stability. We have used the algorithm H2r to identify positions k in the MSAs of the enzymes anthranilate...
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