Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren's syndrome.

RMD open - 1 Dec 2021

Norheim Katrine Brække, Imgenberg-Kreuz Juliana, Alexsson Andrei, Johnsen Svein Joar Auglænd, Bårdsen Kjetil, Brun Johan Gorgas, Dehkordi Rezvan Kiani, Theander Elke, Mandl Thomas, Jonsson Roland, Ng Wan-Fai, Lessard Christopher J, Rasmussen Astrid, Sivilis Kathy, Ronnblom Lars, Omdal Roald

Abstract excerpt

OBJECTIVES: Fatigue is common and severe in primary Sjögren's syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study. METHODS: Patients with pSS from Norway, Sweden, UK and USA with fatigue and genotype data available were included. After genotype imputation and quality control, 682 patients and 4 966 157 genetic markers were available....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatigue

Share to Genome-Wide Association Study

Share to Mannose-Binding Protein-Associated Serine Proteases

Share to Sjogren's Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 34907023
DOI: 10.1136/rmdopen-2021-001832
PMCID: PMC8671987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren's syndrome.PMID 34907023Read ↗

A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study.Semantic proximity Read ↗

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren's Syndrome Patients with FatigueSemantic proximity Read ↗

Uncovering potential single nucleotide polymorphisms, copy number variations and related signaling pathways in primary Sjogren's syndrome.Semantic proximity Read ↗

A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome.Semantic proximity Read ↗

Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome.Semantic proximity Read ↗

Genetic Variants of the BAFF Gene and Risk of Fatigue Among Patients With Primary Sjögren's Syndrome.Semantic proximity Read ↗

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndromeSemantic proximity Read ↗

Epigenome-wide DNA methylation patterns associated with fatigue in primary Sjögren’s syndromeSemantic proximity Read ↗

A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome.Semantic proximity Read ↗

Genetics and epigenetics in primary Sjögren’s syndromeSemantic proximity Read ↗

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndromeSemantic proximity Read ↗

KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.