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Genetics and epigenetics in primary Sjögren’s syndrome

18 Oct 2018

Abstract excerpt

Primary Sjögren's syndrome (pSS) is considered to be a multifactorial disease, where underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to disease development. In the last 5 years, the first genome-wide association studies in pSS have been completed. The strongest signal of association lies within the HLA genes, whereas the non-HLA genes IRF5 and STAT4 show consistent...

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PMID: 30770922
DOI: 10.1093/rheumatology/key330

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