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One-shot high-resolution melting curve analysis for KRAS point-mutation discrimination on a digital microfluidics platform.

Lab on a chip - 1 Feb 2022

Li Mingzhong, Wan Liang, Law Man-Kay, Meng Li, Jia Yanwei, Mak Pui-In, Martins Rui P

Abstract excerpt

Single-nucleotide polymorphism (SNP) plays a critical role in personalized medicine, forensics, pharmacogenetics, and disease diagnostics. Among different existing SNP genotyping techniques, melting curve analysis (MCA) becomes increasingly popular due to its high accuracy and straightforward procedures in extracting the melting temperature (Tm). Yet, its study on existing digital microfluidic (DMF) platforms has...

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PMID: 34904611
DOI: 10.1039/d1lc00564b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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