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Multiplex Digital Polymerase Chain Reaction on a Droplet Array SlipChip for Analysis of KRAS Mutations in Pancreatic Cancer.

ACS sensors - 27 Jan 2023

Hu Qixin, Kanwal Fariha, Lyu Weiyuan, Zhang Jiajie, Liu Xu, Qin Kai, Shen Feng

Abstract excerpt

Pancreatic cancer is a terminal disease with high mortality and very poor prognosis. A sensitive and quantitative analysis of KRAS mutations in pancreatic cancer provides a tool not only to understand the biological mechanisms of pancreatic cancer but also for diagnosis and treatment monitoring. Digital polymerase chain reaction (PCR) is a promising tool for KRAS mutation analysis, but current methods generally...

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PMID: 36520653
DOI: 10.1021/acssensors.2c01776

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