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Genomic instability and colorectal cancer

1 Jan 2000

Abstract excerpt

Colon cancer results from the accumulation of genetic alterations. Genomic instability creates a permissive state in which a potential cancer cell is allowed to acquire enough mutations to become a cancer cell. Several forms of genomic instability are common in colon cancer: microsatellite instability (MSI), chromosome instability (CIN), and chromosome translocations. MSI occurs in approximately 15% of colon...

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PMID: 17024019
DOI: 10.1097/00001574-200001000-00012

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