Article
Immunohistochemistry as a Surrogate Marker of Underlying Molecular Derangements in Sporadic Colorectal Carcinoma in Children - A Series of Three Cases.
Fetal and pediatric pathology - 1 Feb 2022
Maity Priyanka, Halder Aniket, Ghosh Ranajoy, Chatterjee Uttara, Barman Shibsankar, Sarkar Ruchirendra
Abstract excerpt
Background: Colorectal carcinomas (CRCs) are uncommon tumors in children. Here, we elucidate three cases of childhood CRCs with their underlying molecular derangements using immunohistochemistry (IHC) with emphasis on BRAF mutation. Case summary: All three CRCs were sporadic tumors involving the left colon with two of them having a mucinous phenotype. We performed IHC for BRAF, p53 and β-catenin along with...
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