4q22.1 contributes to bone mineral density and osteoporosis susceptibility in postmenopausal women of Chinese Han population.

doi:10.1371/journal.pone.0080165

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Article

4q22.1 contributes to bone mineral density and osteoporosis susceptibility in postmenopausal women of Chinese Han population.

PloS one - 1 Jan 2013

Yang Haojie, Zhang Bo, Zhu Jialin, Liu Dan, Guan Fanglin, He Xijing

Abstract excerpt

Osteoporosis is a multifactorial disease in which genetic determinants are modulated by hormonal, environmental and nutritional factors. An important clinical risk factor in the pathogenesis of osteoporosis is the presence of genetics polymorphism in/around susceptibility genes/regions. This study explored whether the region of 4q22.1, which confers risk of developing osteoporosis in some populations, associated...

Topics

Bone Density
China
Chromosomes, Human, Pair 4
Ethnicity
Genetic Predisposition to Disease
Humans
Middle Aged
Osteoporosis
Polymorphism, Single Nucleotide
Postmenopause

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Identifiers

PMID: 24278256
DOI: 10.1371/journal.pone.0080165
PMCID: PMC3836996

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