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Global burden of high BMI-related osteoarthritis and causal effects of obesity: a GBD 1990–2021 and bidirectional two-sample Mendelian randomization study

6 Aug 2025

Abstract excerpt

BACKGROUND: Osteoarthritis is the most prevalent joint disorder, and osteoarthritis associated with high BMI contributes significantly to the global disease burden. The aim of this study is to elucidate the burden of BMI-related osteoarthritis and to investigate the causal relationship between varying degrees of obesity and osteoarthritis. METHODS: The Global Burden of Disease (GBD) 2021 study was used to conduct...

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PMID: 40788017
DOI: 10.1097/js9.0000000000003133

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