Article
Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms.
Cancer - 1 Sept 2003
Rosenwald Igor B, Wang Songtao, Savas Lou, Woda Bruce, Pullman James
Abstract excerpt
BACKGROUND: Stimulation of resting cells by growth factors leads to an increase in the rate of protein synthesis, which is necessary for cell growth and division. Translation initiation factor eIF-2alpha is one of the key translation factors mediating the effects of growth factors on protein synthesis. In normal cells, expression of eIF-2alpha is increased transiently, but its levels are elevated constitutively...
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